Severe kidney disease may make it necessary to reduce or omit chromium and zinc doses because these elements are primarily eliminated in the urine. Biliary excretion via the small intestine may be an ancillary route, but only small amounts of chromium are believed to be excreted in this manner.ĭirect intramuscular or intravenous injection of Chromium 4 mcg/mL (Chromic Chloride Injection, USP) is contraindicated, as the acidic pH of the solution may cause considerable tissue irritation. This response is viewed as a more meaningful indicator of chromium nutriture than serum chromium levels.Įxcretion of chromium is via the kidneys, ranging from 3 to 50 mcg/day. Administration of chromium supplements to chromium-deficient patients can result in normalization of the glucose tolerance curve from the diabetic-like curve typical of chromium deficiency. Typical blood levels for chromium range from 1 to 5 mcg/liter, but blood levels are not considered a meaningful index of tissue stores. Serum chromium is bound to transferrin (siderophilin) in the beta globulin fraction. Providing chromium during TPN helps prevent deficiency symptoms including impaired glucose tolerance, ataxia, peripheral neuropathy and a confusional state similar to mild/moderate hepatic encephalopathy. Chromium helps to maintain normal glucose metabolism and peripheral nerve function. Trivalent chromium is part of glucose tolerance factor, an essential activator of insulin-mediated reactions. The small amount of water vapor that can pass through the plastic container wall will not significantly alter the drug concentration. The safety of the plastic has been confirmed by tests in animals according to USP biological standards for plastic containers. It is a copolymer of ethylene and propylene. The semi-rigid vial is fabricated from a specially formulated polyolefin. Sodium Chloride, USP is chemically designated NaCl, a white, crystalline compound freely soluble in water. 6H 2O, a crystalline compound soluble in water.The osmolarity is 0.308 mOsm/mL (calc.).Ĭhromic Chloride, USP is chemically designated chromic chloride, hexahydrate CrCl 3 The pH is 2.0 (1.5 to 2.5) product may contain hydrochloric acid and/or sodium hydroxide for pH adjustment. The solution contains no bacteriostat, antimicrobial agent, or added buffer. Each mL of solution contains 20.5 mcg chromic chloride, hexahydrate and 9 mg sodium chloride. Chromium 4 mcg/mL (Chromic Chloride Injection, USP) is a sterile, nonpyrogenic solution intended for use as an additive to intravenous solutions for total parenteral nutrition (TPN).
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